Journal: bioRxiv

Article Title: 3D printed bioelectronic scaffolds with soft tissue-like stiffness

doi: 10.1101/2024.07.19.604334

Figure Lengend Snippet: A) Representative images of samples after post-treatment. B-E) Post-treatment with solvents or acids influences the B) elastic modulus, C) volumetric swelling (percentage relative to as-fabricated hydrogels, without treatment), D) water fraction and E) electronic conductivity of hydrogels. F-G) X-ray S 2p photoelectron spectra of treated and as-fabricated hydrogels indicates a decrease in PSS after all treatments. The de-convoluted profiles were fitted with asymmetric functions. Mean and standard deviation presented. Quantification of PSS/PEDOT ratio calculated from a comparison of the area under the curves of the XPS fits. N≥4. One-way analysis of variance (ANOVA) and Dunnett’s multiple comparison test performed. ****P≤0.0001, ***P≤0.001, **P≤0.01, *P≤0.05, Non-Significant (NS) P>0.05. H) Pearson’s correlation heatmap showing the correlation between PSS/PEDOT ratio (P), water fraction (W), elastic modulus (M) and conductivity (C). I) Survey of recent literature that report modulus and conductivity of 3D printed PEDOT:PSS hydrogels. High conductivity often leads to stiffness values outside the physiological range. The present study joins very few others able to meet satisfactory conductivity with elastic moduli representing soft tissues.

Article Snippet: For statistical analysis, ordinary one-way ANOVA with Sıdak’s or Dunnett’s multiple comparison tests were performed with GraphPad Prism.

Techniques: Standard Deviation, Comparison

Journal: bioRxiv

Article Title: 3D printed bioelectronic scaffolds with soft tissue-like stiffness

doi: 10.1101/2024.07.19.604334

Figure Lengend Snippet: A) Representative strain amplitude sweep of treated and untreated hydrogels to determine the storage modulus (10 rad⋅s -1 , 25 °C). B) Storage modulus obtained from A. One-way analysis of variance (ANOVA) and Dunnett’s multiple comparison test performed. ****P≤0.0001, ***P≤0.001, **P≤0.01, *P≤0.05, Non-Significant (NS) P>0.05. C) Post-treatment causes a decrease in dimensions. The shrinkage occurs nearly isotopically ( xy/z = 0.94 – 1.16). N≥4. Mean and standard deviation presented.

Article Snippet: For statistical analysis, ordinary one-way ANOVA with Sıdak’s or Dunnett’s multiple comparison tests were performed with GraphPad Prism.

Techniques: Comparison, Standard Deviation